# Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

*PRI Rank #6 · Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 75 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.10.027 |
| Corresponding authors | Jing Guo, Gilbert Di Paolo |
| Institution | Denali Therapeutics Inc., United States |

**Ranking page:** [Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026](https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026)

**Paper link:** [10.1016/j.cell.2024.10.027](https://doi.org/10.1016/j.cell.2024.10.027)

## Topics

apolipoprotein E (APOE) · late-onset Alzheimer's disease (LOAD) · ApoE isoforms · low-density lipoprotein receptor (LDLR) · lipidated ApoE2 (lipApoE2) · LDLR recycling defects · cholesteryl esters (CEs) · polyunsaturated fatty acids (PUFAs) · lipofuscinosis · lipid peroxidation · lysosomal pathology · tau fibrils · APOE4 mouse model · intrahippocampal injection · Christchurch mutation · endolysosomal targeting · ApoE-receptor interactions · neurodegeneration · human neurons · allelic series

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026. https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```