# Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome

*PRI Rank #4 · Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026/rank-4*

| Field | Value |
| --- | --- |
| Rank | #4 |
| 18m citations | 81 |
| Journal | Advanced Drug Delivery Reviews |
| Year | 2024 |
| DOI | 10.1016/j.addr.2024.115446 |
| Corresponding authors | Michael J. Mitchell |
| Institution | University of Pennsylvania, United States |

**Ranking page:** [Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026](https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026)

**Paper link:** [10.1016/j.addr.2024.115446](https://doi.org/10.1016/j.addr.2024.115446)

## Topics

cationic lipids · Ionizable lipids · Lipid nanoparticles · Endosomal release · lipid structure evolution · LNP design · intracellular delivery · pKa optimization · lipid chemistry · nucleic acid delivery · Membrane fusion · pH-responsive lipids · Transfection efficiency · lipid-mediated delivery · endosome membrane disruption

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026. https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```