# Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

*PRI Rank #15 · Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 43 |
| Journal | Molecular Cell |
| Year | 2024 |
| DOI | 10.1016/j.molcel.2024.02.029 |
| Corresponding authors | Hemmo Meyer |
| Institution | University of Duisburg-Essen, Germany |

**Ranking page:** [Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026](https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026)

**Paper link:** [10.1016/j.molcel.2024.02.029](https://doi.org/10.1016/j.molcel.2024.02.029)

## Topics

SPG20 · ITCH · lysophagy · Lysosomal rupture · lipid-packing defects · Amphipathic helices · IST1 · lysine-63-linked ubiquitin chains · lipid bilayer perturbations · lysosomal damage sensing · membrane repair · lipid peroxidation · ubiquitin-triggered lysophagy · lysosomal damage response · neurodegeneration

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026. https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```