# Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel

*PRI Rank #14 · Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 48 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-023-44366-w |
| Corresponding authors | Wayland W.L. Cheng |
| Institution | Washington University School of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026](https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026)

**Paper link:** [10.1038/s41467-023-44366-w](https://doi.org/10.1038/s41467-023-44366-w)

## Topics

lipid nanodiscs · pentameric ligand-gated ion channel · Erwinia ligand-gated ion channel · Erwinia ligand-gated ion channel · Erwinia ligand-gated ion channel · cryo-electron microscopy · cryo-EM · nanodisc scaffold · nanodisc size · extracellular domain · agonist binding site · molecular dynamic simulations · nanodisc-protein interactions · membrane protein reconstitution · transmembrane domain structure

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026. https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```