# Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection

*PRI Rank #12 · Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 51 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-45666-5 |
| Corresponding authors | Alexander Kros, Thomas H. Sharp |
| Institution | Leiden University, Netherlands |

**Ranking page:** [Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026](https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026)

**Paper link:** [10.1038/s41467-024-45666-5](https://doi.org/10.1038/s41467-024-45666-5)

## Topics

Lipid nanoparticles · siRNA delivery · inverse hexagonal phases · liquid crystalline structures · lamellar phases · cryogenic transmission electron microscopy · cryogenic electron tomography · small-angle X-ray scattering · intracellular silencing efficiency · anionic membranes · lamellar-to-hexagonal phase transition · cytosolic delivery · programmable lipid phases · LNP core structure · Nano-bio interface · bottom-up rational design

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Lipid Membrane Structure and Behavior Papers, Class of 2026. https://pri.pepkio.com/top-papers/lipid-membrane-structure-and-behavior/2026. Accessed 2026-10-28.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```