# State-Dependent Inhibition of Nav1.8 Sodium Channels by VX-150 and VX-548

*PRI Rank #8 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 42 |
| Journal | Molecular Pharmacology |
| Year | 2024 |
| DOI | 10.1124/molpharm.124.000944 |
| Corresponding authors | Xiao Ma, Bruce P. Bean |
| Institution | Harvard Medical School, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1124/molpharm.124.000944](https://doi.org/10.1124/molpharm.124.000944)

## Topics

Nav1.8 · VX-150 · VX-548 · state-dependent inhibition · Sodium channel blockers · selective Nav1.8 blockers · pain signaling · nociceptor excitability · use-dependent block · electrophysiology · Patch-clamp recording

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```