# Glutamate acts on acid-sensing ion channels to worsen ischaemic brain injury

*PRI Rank #7 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 44 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07684-7 |
| Corresponding authors | Haibo Shi, Lu‐Yang Wang, Shankai Yin |
| Institution | Shanghai Sixth People's Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41586-024-07684-7](https://doi.org/10.1038/s41586-024-07684-7)

## Topics

glutamate · Acid-sensing ion channels · Acid-sensing ion channels · ASIC1a · NMDA receptor · NMDA receptor · l-AP5 · Ischemic stroke · acidosis-induced neurotoxicity · Positive allosteric modulators · glutamate-binding cavity · site-directed mutagenesis · Structure-based drug design · computational drug screening · LK-2 · ASIC1a knockout · Infarct volume · Behavioral recovery · proton affinity · open probability

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```