# Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow

*PRI Rank #5 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-5*

| Field | Value |
| --- | --- |
| Rank | #5 |
| 18m citations | 50 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-52969-0 |
| Corresponding authors | Osama F. Harraz |
| Institution | University of Vermont, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41467-024-52969-0](https://doi.org/10.1038/s41467-024-52969-0)

## Topics

PIEZO1 · endothelial mechanosensor · hyperemia · cerebral blood flow regulation · neurovascular coupling · hemodynamic forces · mechano-feedback · Genetically engineered mouse model · blood flow recovery · memory deficits · brain perfusion · cerebrovascular endothelial cells · neural activity-induced hyperemia · mechanotransduction · vascular response sculpting

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```