# Structural biology and molecular pharmacology of voltage-gated ion channels

*PRI Rank #3 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 74 |
| Journal | Nature Reviews Molecular Cell Biology |
| Year | 2024 |
| DOI | 10.1038/s41580-024-00763-7 |
| Corresponding authors | Jian Huang |
| Institution | Princeton University, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41580-024-00763-7](https://doi.org/10.1038/s41580-024-00763-7)

## Topics

voltage-gated ion channels · structural biology · Pharmacology · Cryo-electron microscopy · X-ray crystallography · channel gating mechanisms · Voltage-sensing domain · Pore domain · Sodium channels · Potassium channels · Calcium channels · Drug binding site · channel modulators · Structure-function relationship · electrophysiology

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```