# Amplifying Ca2+ overload by engineered biomaterials for synergistic cancer therapy

*PRI Rank #20 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 27 |
| Journal | Biomaterials |
| Year | 2024 |
| DOI | 10.1016/j.biomaterials.2024.123027 |
| Corresponding authors | Jun‐Long Liang, Bing Xiao, Jihong Sun |
| Institution | Zhejiang University, China |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1016/j.biomaterials.2024.123027](https://doi.org/10.1016/j.biomaterials.2024.123027)

## Topics

Calcium overload · engineered biomaterials · Combination therapy · Calcium dysregulation · nanomaterial-mediated calcium delivery · apoptosis induction · mitochondrial dysfunction · calcium-based therapeutic strategy · biocompatible calcium carriers · tumor microenvironment modulation · Combination therapy · intracellular calcium elevation · Calcium dysregulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```