# Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders

*PRI Rank #19 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 29 |
| Journal | Nature Communications |
| Year | 2024 |
| DOI | 10.1038/s41467-024-51791-y |
| Corresponding authors | Marco Miotto, Andrew R. Marks |
| Institution | Columbia University, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41467-024-51791-y](https://doi.org/10.1038/s41467-024-51791-y)

## Topics

Ryanodine receptor type 2 · Ryanodine receptor type 2 · heart failure · arrhythmogenic disorders · Calcium leak · Calstabin2 · hyperphosphorylation · oxidation · Cryo-electron microscopy · Cryo-electron microscopy · primed state · Rycal drugs · sudden cardiac death · cardiac contractility · genetic mutations · Closed conformation · Open conformation · sarcoplasmic reticulum · Calcium leak · arrhythmias

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```