# Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8

*PRI Rank #15 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 30 |
| Journal | Science Advances |
| Year | 2024 |
| DOI | 10.1126/sciadv.adp2211 |
| Corresponding authors | Seok‐Yong Lee |
| Institution | Duke University, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1126/sciadv.adp2211](https://doi.org/10.1126/sciadv.adp2211)

## Topics

TRPM8 · sensory adaptation · desensitization · TRPM8 · TRPM8 · Cryo-electron microscopy · electrophysiology · Molecular dynamics simulation · TRPM8 inhibitors · State-dependent binding · cold-evoked pain · migraine · cooling agonists · Conformational change · structural determinants · desensitization pathway · cold sensation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```