# TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site

*PRI Rank #14 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 33 |
| Journal | Science Advances |
| Year | 2024 |
| DOI | 10.1126/sciadv.adn2453 |
| Corresponding authors | Alexander I. Sobolevsky |
| Institution | Columbia University, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1126/sciadv.adn2453](https://doi.org/10.1126/sciadv.adn2453)

## Topics

TRPV3 · Cryo-electron microscopy · TRPV3 · tetrahydrocannabivarin (THCV) · 2-aminoethoxydiphenylborane (2-APB) · vanilloid site · S1-S4 base binding site · ARD-TMD linker site · lipid dissociation · Channel opening · channel inactivation · allosteric pathways · ligand-activated TRP channel · Temperature-gated ion channels · cannabinoid agonist · synthetic agonist

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```