# Structural basis of TRPV1 modulation by endogenous bioactive lipids

*PRI Rank #12 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 35 |
| Journal | Nature Structural & Molecular Biology |
| Year | 2024 |
| DOI | 10.1038/s41594-024-01299-2 |
| Corresponding authors | David Julius, Yifan Cheng |
| Institution | University of California San Francisco, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41594-024-01299-2](https://doi.org/10.1038/s41594-024-01299-2)

## Topics

TRPV1 · phosphoinositide lipids · lysophosphatidic acid · lipid regulatory pocket · capsaicin · Thermal activation · inflammatory pain · transmembrane core · TRPV1 · negative modulation · agonist-like state · lipid binding modes · Thermal activation · chemical stimuli · pro-algesic agents · endogenous lipid · TRP channels · lipid ejection mechanism

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```