# Interplay of Nav1.8 and Nav1.7 channels drives neuronal hyperexcitability in neuropathic pain

*PRI Rank #11 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-11*

| Field | Value |
| --- | --- |
| Rank | #11 |
| 18m citations | 36 |
| Journal | The Journal of General Physiology |
| Year | 2024 |
| DOI | 10.1085/jgp.202413596 |
| Corresponding authors | Dmytro V Vasylyev |
| Institution | Yale University, United States |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1085/jgp.202413596](https://doi.org/10.1085/jgp.202413596)

## Topics

Nav1.8 · Nav1.7 · dorsal root ganglion neurons · neuronal hyperexcitability · neuropathic pain · dynamic clamp · Nav1.7L848H · Gain-of-function mutation · inherited erythromelalgia · action potential threshold · channel open-probability · rheobase · subthreshold membrane potential oscillations · firing probability · kinetic model · Nav1.8 conductance reduction · small DRG neurons · electrogenesis · Voltage-gated sodium channels

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```