# An intermediate open structure reveals the gating transition of the mechanically activated PIEZO1 channel

*PRI Rank #10 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 37 |
| Journal | Neuron |
| Year | 2024 |
| DOI | 10.1016/j.neuron.2024.11.020 |
| Corresponding authors | Boxue Tian, Xueming Li, Bailong Xiao |
| Institution | Tsinghua University, China |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1016/j.neuron.2024.11.020](https://doi.org/10.1016/j.neuron.2024.11.020)

## Topics

PIEZO1 · Mechanosensitive ion channels · intermediate open structure · gating transition · Cryo-electron microscopy · Mechanosensitive ion channels · channel opening mechanism · conformational states · structural biology · membrane protein structure

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```