# Mechanisms of mechanotransduction and physiological roles of PIEZO channels

*PRI Rank #1 · Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 199 |
| Journal | Nature Reviews Molecular Cell Biology |
| Year | 2024 |
| DOI | 10.1038/s41580-024-00773-5 |
| Corresponding authors | Bailong Xiao |
| Institution | Tsinghua University, China |

**Ranking page:** [Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026](https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026)

**Paper link:** [10.1038/s41580-024-00773-5](https://doi.org/10.1038/s41580-024-00773-5)

## Topics

Piezo channels · mechanotransduction · Mechanosensitive ion channels · PIEZO1 · PIEZO2 · mechanical force sensing · Ion channel gating · physiological roles · touch sensation · proprioception · vascular development · red blood cell volume regulation · baroreception · Mechanosensitive currents · Structure-function relationship · sensory transduction · cellular mechanosensing

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Ion channel regulation and function Papers, Class of 2026. https://pri.pepkio.com/top-papers/ion-channel-regulation-and-function/2026. Accessed 2026-07-22.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```