# A single mutation G454A in the P450 <i>CYP9K1</i> drives pyrethroid resistance in the major malaria vector <i>Anopheles funestus</i> reducing bed net efficacy

*PRI Rank #7 · Topics and Trends in Most Cited Insect Resistance and Genetics Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/insect-resistance-and-genetics/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 32 |
| Journal | Genetics |
| Year | 2024 |
| DOI | 10.1093/genetics/iyae181 |
| Corresponding authors | Carlos S. Djoko Tagne, Charles S. Wondji |
| Institution | Centre for Research in Infectious Diseases (CRID), Cameroon |

**Ranking page:** [Topics and Trends in Most Cited Insect Resistance and Genetics Papers, Class of 2026](https://pri.pepkio.com/top-papers/insect-resistance-and-genetics/2026)

**Paper link:** [10.1093/genetics/iyae181](https://doi.org/10.1093/genetics/iyae181)

## Topics

CYP9K1 G454A mutation · CYP9K1 · cytochrome P450 · pyrethroid resistance · Anopheles funestus · metabolic resistance · Insecticide-treated nets · deltamethrin metabolism · type II pyrethroids · type I pyrethroids · haplotype selection · Drosophila melanogaster · heterologous expression · Experimental hut trial · DNA-based resistance assay · directional selection · CYP9K1 G454A mutation · field-lab-field approach

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Insect Resistance and Genetics Papers, Class of 2026. https://pri.pepkio.com/top-papers/insect-resistance-and-genetics/2026. Accessed 2026-07-23.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```