# Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

*PRI Rank #9 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 160 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08171-9 |
| Corresponding authors | Michelle Monje, Sneha Ramakrishna, Crystal L. Mackall |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41586-024-08171-9](https://doi.org/10.1038/s41586-024-08171-9)

## Topics

H3K27M-mutant diffuse midline gliomas · disialoganglioside GD2 · GD2-CAR T cells · diffuse intrinsic pontine glioma · spinal diffuse midline glioma · intravenous administration · intracerebroventricular infusion · Lymphodepletion · Dose-limiting toxicity · cytokine release syndrome · tumor inflammation-associated neurotoxicity · volumetric tumor reduction · complete response · neurological benefit · clinical improvement score · autologous CAR T cell therapy · maximally tolerated dose

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```