# Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity

*PRI Rank #7 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 179 |
| Journal | Nature reviews. Cancer |
| Year | 2024 |
| DOI | 10.1038/s41568-024-00674-x |
| Corresponding authors | Dieter Adam, John Silke |
| Institution | Institute of Cancer Research, United Kingdom |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41568-024-00674-x](https://doi.org/10.1038/s41568-024-00674-x)

## Topics

immunogenic cell death · necroptosis · antitumor immunity · RIPK1 · RIPK3 · MLKL · Damage-associated molecular patterns (DAMPs) · Damage-associated molecular patterns (DAMPs) · tumor microenvironment · cancer immunotherapy · dendritic cell activation · T cell priming · necrosome · caspase-8 · inflammatory cytokines · necroptosis inducers · tumor-infiltrating lymphocytes · immune checkpoint blockade

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```