# Spatiotemporal single-cell analysis decodes cellular dynamics underlying different responses to immunotherapy in colorectal cancer

*PRI Rank #20 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 108 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.06.009 |
| Corresponding authors | Dongfang Wang, Aiwen Wu, Zemin Zhang |
| Institution | Peking University, China |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1016/j.ccell.2024.06.009](https://doi.org/10.1016/j.ccell.2024.06.009)

## Topics

spatiotemporal single-cell analysis · immunotherapy response · colorectal cancer · cellular dynamics · tumor microenvironment · single-cell RNA sequencing · spatial omics · immune checkpoint inhibitors · immune cell infiltration · tumor-infiltrating lymphocytes · cancer-associated fibroblasts · myeloid cells · Resistance mechanisms · responder vs non-responder · temporal evolution

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```