# Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors

*PRI Rank #19 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 113 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.05.025 |
| Corresponding authors | Gabriel Espinosa-Carrasco, Andrea Schietinger |
| Institution | Memorial Sloan Kettering Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1016/j.ccell.2024.05.025](https://doi.org/10.1016/j.ccell.2024.05.025)

## Topics

intratumoral immune triads · immunotherapy-mediated tumor elimination · solid tumors · tertiary lymphoid structures · CD8+ T cells · B cells · dendritic cells · tumor-infiltrating lymphocytes · immune checkpoint blockade · antitumor immunity · spatial organization of immune cells · T cell-B cell interactions · tumor microenvironment · immune cell clustering · therapeutic response prediction

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```