# CD19-CAR T-cell therapy induces deep tissue depletion of B cells

*PRI Rank #18 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 114 |
| Journal | Annals of the Rheumatic Diseases |
| Year | 2024 |
| DOI | 10.1136/ard-2024-226142 |
| Corresponding authors | Maria Gabriella Raimondo |
| Institution | Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1136/ard-2024-226142](https://doi.org/10.1136/ard-2024-226142)

## Topics

CD19 CAR T-cell therapy · autoimmune diseases · deep tissue B-cell depletion · ultrasound-guided inguinal lymph node biopsies · rituximab · CD19+ B cells · CD20+ B cells · follicular dendritic cells · Plasma cells · follicular structure disruption · secondary lymphoid tissues · non-lymphoid organ biopsies · Lymphodepletion · immunohistochemistry · drug-free remission

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```