# Cancer cells impair monocyte-mediated T cell stimulation to evade immunity

*PRI Rank #17 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 118 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08257-4 |
| Corresponding authors | Anna C. Obenauf |
| Institution | Research Institute of Molecular Pathology (IMP), Austria |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41586-024-08257-4](https://doi.org/10.1038/s41586-024-08257-4)

## Topics

inflammatory monocytes · intratumoral T cell stimulation · type 1 conventional dendritic cells · cross-dressing · peptide-MHC complexes · MAPK signalling hyperactivation · Type I interferon (IFN-I) · Prostaglandin E2 (PGE2) · CXCL9 · Cxcl10 · IL-15 · cross-presentation · CD8+ T cells · tumor microenvironment · cytotoxic effector differentiation · oncogenic signalling · IFN-I cytokine production · PGE2 secretion blockade · T cell-mediated immunity

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```