# Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results

*PRI Rank #16 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 118 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-024-03037-z |
| Corresponding authors | Changsong Qi |
| Institution | Peking University Cancer Hospital & Institute, China |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41591-024-03037-z](https://doi.org/10.1038/s41591-024-03037-z)

## Topics

Claudin18.2 · CAR T-cell therapy · gastrointestinal cancers · Phase I clinical trial · Claudin18.2-specific CAR T cells · tumor-associated antigen · solid tumor immunotherapy · CAR T cell therapy toxicity · Objective response rate (ORR) · gastric cancer · pancreatic cancer · esophageal cancer · CLDN18.2 expression · cytokine release syndrome · on-target off-tumor toxicity · CAR T cell persistence · antitumor efficacy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```