# Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial

*PRI Rank #15 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 122 |
| Journal | Nature Medicine |
| Year | 2024 |
| DOI | 10.1038/s41591-023-02760-3 |
| Corresponding authors | Shubham Pant, Christopher M. Haqq, Eileen M. O’Reilly |
| Institution | The University of Texas MD Anderson Cancer Center, United States |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41591-023-02760-3](https://doi.org/10.1038/s41591-023-02760-3)

## Topics

ELI-002 2P · amphiphile modification · KRAS G12D mutation · KRAS G12R mutation · Amph-Peptides-2P · Amph-CpG-7909 · lymph node delivery · Minimal residual disease (MRD) · ctDNA · serum tumor antigen · mKRAS-specific T cell responses · CD4+ T cells · CD8+ T cells · tumor biomarker clearance · relapse-free survival · ex vivo T cell assay · CpG oligonucleotide adjuvant · phase 1 dose escalation · recommended phase 2 dose

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```