# Probiotic neoantigen delivery vectors for precision cancer immunotherapy

*PRI Rank #13 · Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 128 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08033-4 |
| Corresponding authors | Tal Danino, Nicholas Arpaia |
| Institution | Columbia University, United States |

**Ranking page:** [Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026](https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026)

**Paper link:** [10.1038/s41586-024-08033-4](https://doi.org/10.1038/s41586-024-08033-4)

## Topics

Escherichia coli Nissle 1917 · probiotic cancer vaccine · neoepitope peptide arrays · cytosolic delivery · bacterial tumor homing · Engineered probiotic · neoantigen-specific CD8+ T cells · neoantigen-specific CD4+ T cells · dendritic cell activation · natural killer cell activation · regulatory T cells · immunosuppressive myeloid cells · metastatic solid tumors · blood clearance susceptibility · phagocytosis enhancement · antitumor T cell immunity · living medicine platform · synthetic bacterial engineering · tumor microenvironment modulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immunotherapy and Immune Responses Papers, Class of 2026. https://pri.pepkio.com/top-papers/immunotherapy-and-immune-responses/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```