# A blueprint for tumor-infiltrating B cells across human cancers

*PRI Rank #9 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-9*

| Field | Value |
| --- | --- |
| Rank | #9 |
| 18m citations | 128 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adj4857 |
| Corresponding authors | Jiaqiang Ma, Yingcheng Wu, Lifeng Ma, Xupeng Yang, Tiancheng Zhang, Jia Fan, Guoji Guo, Xiaoming Zhang, Qiang Gao |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1126/science.adj4857](https://doi.org/10.1126/science.adj4857)

## Topics

Tumor-infiltrating B cells · Single-cell transcriptomics · B cell-receptor repertoire · chromatin accessibility · extrafollicular pathway · germinal center pathway · B cell subsets · dysfunctional extrafollicular program · glutamine-derived metabolites · epigenetic-metabolic cross-talk · T cell-driven immunosuppressive program · Immunotherapy resistance · humoral immunity · B cell-targeting immunotherapy · intratumor B cell balance

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```