# Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity

*PRI Rank #8 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 129 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07238-x |
| Corresponding authors | Kim J. Hasenkrug, Irving L. Weissman |
| Institution | Stanford University, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41586-024-07238-x](https://doi.org/10.1038/s41586-024-07238-x)

## Topics

myeloid-biased haematopoietic stem cells · Immunosenescence · HSC depletion · immune rejuvenation · Myeloid bias · hematopoietic stem cell aging · Immunosenescence · Myeloid bias · stem cell heterogeneity · clonal hematopoiesis

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```