# LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

*PRI Rank #3 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-3*

| Field | Value |
| --- | --- |
| Rank | #3 |
| 18m citations | 181 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.07.016 |
| Corresponding authors | Dario A.A. Vignali |
| Institution | University of Pittsburgh, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1016/j.cell.2024.07.016](https://doi.org/10.1016/j.cell.2024.07.016)

## Topics

LAG-3 · PD-1 · CD8+ T cell exhaustion · autocrine IFN-γ signaling · Antitumor immunity · immune checkpoint synergy · T cell receptor signaling inhibition

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```