# The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

*PRI Rank #20 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-20*

| Field | Value |
| --- | --- |
| Rank | #20 |
| 18m citations | 105 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07962-4 |
| Corresponding authors | Rong Fan, Yugang Guo, Li Tang |
| Institution | École Polytechnique Fédérale de Lausanne, Switzerland |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41586-024-07962-4](https://doi.org/10.1038/s41586-024-07962-4)

## Topics

Fc–IL-4 · Type 2 cytokines · exhausted CD8+ T cells · Terminally exhausted T cells · Terminally exhausted T cells · type 1 immunity · Adoptive T cell therapy · Immune checkpoint blockade · STAT6 pathway · mTOR pathway · Glycolysis · NAD concentration · lactate dehydrogenase A · LDHA-dependent mechanism · Metabolic reprogramming · type 2 immunity · syngeneic tumour models · xenograft tumour models · cancer immunotherapy synergy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```