# Interleukin-15-armoured GPC3 CAR T cells for patients with solid cancers

*PRI Rank #2 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 196 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-08261-8 |
| Corresponding authors | Andras Heczey |
| Institution | Baylor College of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41586-024-08261-8](https://doi.org/10.1038/s41586-024-08261-8)

## Topics

Interleukin-15 · GPC3 · CAR T cell therapy · Solid tumors · armoured CAR T cells · GPC3 · cytokine armoring · IL-15 secretion · Tumor microenvironment · CAR T cell persistence · solid tumor immunotherapy

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```