# Smoking changes adaptive immunity with persistent effects

*PRI Rank #18 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 108 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-023-06968-8 |
| Corresponding authors | Violaine Saint‐André, Darragh Duffy |
| Institution | Institut Pasteur, France |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41586-023-06968-8](https://doi.org/10.1038/s41586-023-06968-8)

## Topics

cytokine secretion variability · smoking · cytomegalovirus latent infection · body mass index · innate immune responses · Adaptive immunity · smoking cessation · CEACAM6 · epigenetic memory · DNA methylation · signal trans-activators · metabolic regulators · immune challenge response · long-term immunological effects

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```