# JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma

*PRI Rank #17 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 115 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.ade8520 |
| Corresponding authors | Jaroslav Žák, Veronika Bachanová, John R. Teijaro |
| Institution | University of Minnesota, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1126/science.ade8520](https://doi.org/10.1126/science.ade8520)

## Topics

JAK inhibition · Immune checkpoint blockade · Hodgkin lymphoma · ruxolitinib · PD-1/PD-L1 blockade · nivolumab · JAK-STAT pathway · Immunotherapy resistance · neutrophil-to-lymphocyte ratio · Myeloid-derived suppressor cells · T cell exhaustion · immunostimulatory myeloid cells · T cell division · cytokine-producing T cells · relapsed or refractory Hodgkin lymphoma

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```