# IL-10 constrains sphingolipid metabolism to limit inflammation

*PRI Rank #16 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-16*

| Field | Value |
| --- | --- |
| Rank | #16 |
| 18m citations | 115 |
| Journal | Nature |
| Year | 2024 |
| DOI | 10.1038/s41586-024-07098-5 |
| Corresponding authors | Autumn G. York, Steven J. Bensinger, Richard A. Flavell |
| Institution | Yale University, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41586-024-07098-5](https://doi.org/10.1038/s41586-024-07098-5)

## Topics

IL-10 signalling · very long chain ceramides · ceramide synthase 2 (CERS2) · sphingolipid metabolism · inflammatory bowel disease · innate immune cells · mono-unsaturated fatty acid synthesis · fatty acid desaturation · REL transcription factor · IL-10 deficiency · inflammatory gene expression · de novo lipogenesis · genetic deletion of Cers2 · saturated ceramide accumulation · metabolic correction of lipid homeostasis · fatty acid homeostasis in immune regulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```