# Identification of the novel exhausted T cell CD8 + markers in breast cancer

*PRI Rank #15 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-15*

| Field | Value |
| --- | --- |
| Rank | #15 |
| 18m citations | 116 |
| Journal | Scientific Reports |
| Year | 2024 |
| DOI | 10.1038/s41598-024-70184-1 |
| Corresponding authors | Panpan Wang, Jieling Weng |
| Institution | Jinan University, China |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1038/s41598-024-70184-1](https://doi.org/10.1038/s41598-024-70184-1)

## Topics

exhausted CD8+ T cells · CD8Tex marker gene sets · Tumor microenvironment · single-cell immune cell datasets · machine learning clustering · prognostic model · protein-protein interaction network · hub genes · CRTAM · CLEC2D · KLRB1 · breast cancer bulk sequencing data · spatial sequencing data · pan-cancer analysis · Cancer immunotherapy · survival analysis · molecular subtyping · biomarker identification · T cell exhaustion · cancer immunotherapy biomarkers

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```