# Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion

*PRI Rank #14 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-14*

| Field | Value |
| --- | --- |
| Rank | #14 |
| 18m citations | 116 |
| Journal | Immunity |
| Year | 2024 |
| DOI | 10.1016/j.immuni.2024.11.026 |
| Corresponding authors | Jessica Waibl Polania |
| Institution | Duke University, United States |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1016/j.immuni.2024.11.026](https://doi.org/10.1016/j.immuni.2024.11.026)

## Topics

Progenitor exhausted T cells · Terminally exhausted T cells · progenitor exhaustion-to-terminal exhaustion ratio (PETER) · tumor-associated macrophages · antigen presentation · TAM depletion · Immunotherapy response prediction · PD-1/PD-L1 blockade · glioblastoma · single-cell analysis · tumor-specific T cell subsets · cognate antigen exposure · T cell exhaustion trajectory · intratumoral cellular interactions · Progenitor exhausted T cells · anti-tumor cytotoxic function · Tumor progression · Solid tumors · TAM-T cell interactions · Immunotherapy response prediction

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```