# Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation

*PRI Rank #13 · Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026/rank-13*

| Field | Value |
| --- | --- |
| Rank | #13 |
| 18m citations | 117 |
| Journal | Cell Metabolism |
| Year | 2024 |
| DOI | 10.1016/j.cmet.2024.10.019 |
| Corresponding authors | Zhen Lei, Hubing Shi, Xuelei Ma |
| Institution | Sichuan University, China |

**Ranking page:** [Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026](https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026)

**Paper link:** [10.1016/j.cmet.2024.10.019](https://doi.org/10.1016/j.cmet.2024.10.019)

## Topics

serine/glycine-free diet · Colorectal cancer · PD-1/PD-L1 blockade · Lactylation · CD8+ T cells · Antitumor immunity · Immune evasion · PD-1/PD-L1 signaling pathway · CD8+ T cells · diet-immunotherapy combination · Tumor growth inhibition · T cell accumulation · Lactylation · PD-L1 · Solid tumors · Phase I clinical trial · systemic immunity regulation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Immune Cell Function and Interaction Papers, Class of 2026. https://pri.pepkio.com/top-papers/immune-cell-function-and-interaction/2026. Accessed 2026-07-16.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```