# DNA framework signal amplification platform-based high-throughput systemic immune monitoring

*PRI Rank #7 · Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/rank-7*

| Field | Value |
| --- | --- |
| Rank | #7 |
| 18m citations | 50 |
| Journal | Signal Transduction and Targeted Therapy |
| Year | 2024 |
| DOI | 10.1038/s41392-024-01736-0 |
| Corresponding authors | Yi Li, Taoran Tian, Yunfeng Lin |
| Institution | Sichuan University, China |

**Ranking page:** [Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026)

**Paper link:** [10.1038/s41392-024-01736-0](https://doi.org/10.1038/s41392-024-01736-0)

## Topics

DNA framework signal amplification platform · DNA framework signal amplification platform · systemic immune monitoring · flow cytometry · high-throughput immune monitoring · SELEX · SELEX · DNA tetrahedral framework · CD4+ T cells · CD8+ T cells · monocytes · Immunophenotyping · one-step immune-cell phenotyping · People living with HIV (PLHIV) · immunodeficiency staging · point-of-care device · cell washing-free detection · 30-min detection · mass health screening

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```