# mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies

*PRI Rank #6 · Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 50 |
| Journal | Science |
| Year | 2024 |
| DOI | 10.1126/science.adk0582 |
| Corresponding authors | Zhenfei Xie, Ying‐Cing Lin, Jon M. Steichen, Gabriel Ozorowski, Andrew B. Ward, William R. Schief, Facundo D. Batista |
| Institution | Ragon Institute, United States |

**Ranking page:** [Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026)

**Paper link:** [10.1126/science.adk0582](https://doi.org/10.1126/science.adk0582)

## Topics

mRNA-LNP delivery · Germline-targeting immunogens · N332-GT5 trimer · Broadly neutralizing antibodies (bNAbs) · V3-glycan epitope · Humanized mouse models · B cell lineage · Germinal center reactions · epitope masking · B cell receptor modification · somatic hypermutation · affinity maturation · prime-boost immunization strategy · off-target V1-binding responses · B cell lineage · HIV vaccine · lipid nanoparticle formulation · cross-reactivity minimization · HIV vaccine · Broadly neutralizing antibodies (bNAbs)

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```