# Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids

*PRI Rank #19 · Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 32 |
| Journal | PNAS Nexus |
| Year | 2024 |
| DOI | 10.1093/pnasnexus/pgae179 |
| Corresponding authors | Warner C. Greene |
| Institution | Gladstone, United States |

**Ranking page:** [Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026)

**Paper link:** [10.1093/pnasnexus/pgae179](https://doi.org/10.1093/pnasnexus/pgae179)

## Topics

HIV-associated neurocognitive disorder · Antiretroviral therapy (ART) · brain microglia · Cerebral organoids · Cerebral organoids · choroid plexus organoids · CCL2 · CXCL10 · type I interferon stimulated genes · MX1 · ISG15 · ISG20 · IFI27 · IFITM3 · S100 family · single-cell RNA-seq · neurotransmitter transporter expression · cellular senescence · bystander neuronal dysfunction · neuroinflammation propagation

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```