# The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression

*PRI Rank #17 · Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/rank-17*

| Field | Value |
| --- | --- |
| Rank | #17 |
| 18m citations | 34 |
| Journal | Cell |
| Year | 2024 |
| DOI | 10.1016/j.cell.2024.01.048 |
| Corresponding authors | Liang Shan |
| Institution | Washington University School of Medicine, United States |

**Ranking page:** [Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026)

**Paper link:** [10.1016/j.cell.2024.01.048](https://doi.org/10.1016/j.cell.2024.01.048)

## Topics

CARD8 inflammasome · HIV protease · Simian immunodeficiency virus (SIV) · CD4+ T cell depletion · pyroptosis · quiescent cells · sooty mangabeys · natural host · Humanized mouse models · CARD8-deficient cells · virion entry · T cell activation · loss-of-function mutations · uninfected bystander cell death · non-pathogenic infection · AIDS progression

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```