# Twice-Yearly Lenacapavir or Daily F/TAF for HIV Prevention in Cisgender Women

*PRI Rank #1 · Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026/rank-1*

| Field | Value |
| --- | --- |
| Rank | #1 |
| 18m citations | 334 |
| Journal | New England Journal of Medicine |
| Year | 2024 |
| DOI | 10.1056/nejmoa2407001 |
| Corresponding authors | Linda-Gail Bekker |
| Institution | University of Cape Town, South Africa |

**Ranking page:** [Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026](https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026)

**Paper link:** [10.1056/nejmoa2407001](https://doi.org/10.1056/nejmoa2407001)

## Topics

lenacapavir · emtricitabine-tenofovir alafenamide · F/TAF · emtricitabine-tenofovir disoproxil fumarate · F/TDF · HIV pre-exposure prophylaxis (PrEP) · HIV pre-exposure prophylaxis (PrEP) · subcutaneous administration · Twice-yearly dosing · cisgender women · adolescent girls and young women · HIV incidence · HIV incidence · Adherence · injection site reactions · phase 3 trial · PURPOSE 1

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited HIV Research and Treatment Papers, Class of 2026. https://pri.pepkio.com/top-papers/hiv-research-and-treatment/2026. Accessed 2026-07-21.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```