# The #HOPE4LIVER Single-Arm Pivotal Trial for Histotripsy of Primary and Metastatic Liver Tumors

*PRI Rank #8 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-8*

| Field | Value |
| --- | --- |
| Rank | #8 |
| 18m citations | 79 |
| Journal | Radiology |
| Year | 2024 |
| DOI | 10.1148/radiol.233051 |
| Corresponding authors | Luigi Solbiati, Timothy J. Ziemlewicz |
| Institution | Humanitas University & Humanitas Clinical and Research Hospital IRCCS, Italy |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1148/radiol.233051](https://doi.org/10.1148/radiol.233051)

## Topics

histotripsy · liver tumors · primary liver tumors · metastatic liver tumors · HistoSonics System · non-thermal ablation · mechanical tissue destruction · focused ultrasound · Single-arm trial · HOPE4LIVER trial · Ablation therapy · hepatic oncology · non-invasive tumor treatment · ultrasound-based therapy · technical success · safety outcomes · pooled clinical trials

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```