# Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study

*PRI Rank #6 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-6*

| Field | Value |
| --- | --- |
| Rank | #6 |
| 18m citations | 91 |
| Journal | EClinicalMedicine |
| Year | 2024 |
| DOI | 10.1016/j.eclinm.2024.102622 |
| Corresponding authors | Gao‐Jun Teng, Gao-Jun Teng |
| Institution | Southeast University, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1016/j.eclinm.2024.102622](https://doi.org/10.1016/j.eclinm.2024.102622)

## Topics

Hepatocellular carcinoma · Transarterial chemoembolization · Immune checkpoint inhibitor therapy · VEGF inhibition · Tyrosine kinase inhibitor · vascular endothelial growth factor (VEGF) · First-line treatment · Advanced hepatocellular carcinoma · target trial emulation · Inverse probability of treatment weighting · Overall survival · Progression-free survival · Objective response rate · RECIST 1.1 · Modified RECIST (mRECIST) · TACE-ICI-VEGF combination therapy · retrospective cohort study · Multicenter study · hazard ratio · Adverse events · combination immunotherapy · Locoregional therapy · Systemic therapy · tumor response · safety profile · Inverse probability of treatment weighting · First-line treatment · VEGF inhibition · causal inference methods · observational study design

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```