# Four-year overall survival update from the phase III HIMALAYA study of tremelimumab plus durvalumab in unresectable hepatocellular carcinoma

*PRI Rank #2 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-2*

| Field | Value |
| --- | --- |
| Rank | #2 |
| 18m citations | 170 |
| Journal | Annals of Oncology |
| Year | 2024 |
| DOI | 10.1016/j.annonc.2024.02.005 |
| Corresponding authors | B. Sangro |
| Institution | Clínica Universidad de Navarra, Spain |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1016/j.annonc.2024.02.005](https://doi.org/10.1016/j.annonc.2024.02.005)

## Topics

Unresectable hepatocellular carcinoma · HIMALAYA study · Durvalumab plus tremelimumab · tremelimumab · durvalumab · sorafenib · Overall survival · Phase III clinical trial · Immune checkpoint inhibitor therapy · CTLA-4 inhibition · PD-1/PD-L1 inhibitor · combination immunotherapy · Long-term survival · 4-year overall survival · hazard ratio · disease control · Long-term survival · Treatment-related adverse events · subsequent anticancer therapy · First-line treatment · Noninferiority trial · safety profile · subgroup analysis · Randomized controlled trial · survival rate · late-onset safety signals · clinically relevant subgroups · median follow-up · Systemic therapy · hepatocellular carcinoma subgroups

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```