# Biomarkers and prognostic factors of PD-1/PD-L1 inhibitor-based therapy in patients with advanced hepatocellular carcinoma

*PRI Rank #19 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-19*

| Field | Value |
| --- | --- |
| Rank | #19 |
| 18m citations | 45 |
| Journal | Biomarker Research |
| Year | 2024 |
| DOI | 10.1186/s40364-023-00535-z |
| Corresponding authors | Hanping Wang |
| Institution | Peking Union Medical College Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1186/s40364-023-00535-z](https://doi.org/10.1186/s40364-023-00535-z)

## Topics

Hepatocellular carcinoma · PD-1/PD-L1 inhibitor · PD-1/PD-L1 inhibitor · PD-L1 expression · Tumor microenvironment · Tumor-infiltrating lymphocytes · stimulatory dendritic cells · conventional dendritic cells · tumor-associated macrophages · Single-cell RNA sequencing · spatial transcriptomics · Tumor heterogeneity · next-generation sequencing · tumor mutational burden · copy number alterations · TP53 · CTNNB1 · GZMB · Wnt/β-catenin signaling pathway · Child-Pugh class · Performance status · TGF-β signaling · Lactate dehydrogenase (LDH) · alpha-fetoprotein · Des-gamma-carboxyprothrombin · CRAFITY score · liquid biopsy · gut microbiome · EOB-MRI · PET/CT

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```