# APASL clinical practice guidelines on systemic therapy for hepatocellular carcinoma-2024

*PRI Rank #18 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-18*

| Field | Value |
| --- | --- |
| Rank | #18 |
| 18m citations | 49 |
| Journal | Hepatology International |
| Year | 2024 |
| DOI | 10.1007/s12072-024-10732-z |
| Corresponding authors | George Lau |
| Institution | Fudan University, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1007/s12072-024-10732-z](https://doi.org/10.1007/s12072-024-10732-z)

## Topics

Hepatocellular carcinoma · Systemic therapy · Clinical practice guidelines · APASL · sorafenib · lenvatinib · Atezolizumab plus bevacizumab · Durvalumab plus tremelimumab · Immune checkpoint inhibitor therapy · Tyrosine kinase inhibitor · First-line treatment · Second-line therapy · Barcelona Clinic Liver Cancer (BCLC) staging · Child-Pugh class · Overall survival · Progression-free survival · Objective response rate · Hepatitis B virus infection · Hepatitis C virus infection · Cirrhosis · regorafenib · cabozantinib · ramucirumab · nivolumab · pembrolizumab · VEGF signaling pathway · PD-L1 expression · biomarker selection · combination immunotherapy · Adverse event management

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```