# Trends in Hepatocellular Carcinoma Mortality Rates in the US and Projections Through 2040

*PRI Rank #12 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-12*

| Field | Value |
| --- | --- |
| Rank | #12 |
| 18m citations | 66 |
| Journal | JAMA Network Open |
| Year | 2024 |
| DOI | 10.1001/jamanetworkopen.2024.45525 |
| Corresponding authors | Fanpu Ji, Mindie H. Nguyen |
| Institution | The Second Affiliated Hospital of Xi'an Jiaotong University, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1001/jamanetworkopen.2024.45525](https://doi.org/10.1001/jamanetworkopen.2024.45525)

## Topics

Hepatocellular carcinoma · age-standardized mortality rates (ASMRs) · Alcoholic liver disease · Metabolic dysfunction-associated steatotic liver disease (MASLD) · Hepatitis C virus infection · Hepatitis B virus infection · liver cancer mortality · Joinpoint regression · Prophet modeling · AutoARIMA modeling · mortality projections · National Vital Statistics System · cross-sectional study · annual percentage change · Etiology of liver disease · racial and ethnic disparities · American Indian or Alaska Native population · age stratification · sex differences in HCC mortality · HCC incidence · epidemiologic trends · public health decision-making · High-risk population identification · Centers for Disease Control and Prevention · liver cancer burden · mortality trend analysis · HCC-related death projections through 2040 · metabolic liver disease-associated HCC · alcohol-related HCC

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```