# Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer

*PRI Rank #10 · Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026*

*Canonical URL: https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026/rank-10*

| Field | Value |
| --- | --- |
| Rank | #10 |
| 18m citations | 69 |
| Journal | Cancer Cell |
| Year | 2024 |
| DOI | 10.1016/j.ccell.2024.03.004 |
| Corresponding authors | Jiangong Zhang, Jianmin Wu, Ning Zhang |
| Institution | Peking University First Hospital, China |

**Ranking page:** [Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026](https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026)

**Paper link:** [10.1016/j.ccell.2024.03.004](https://doi.org/10.1016/j.ccell.2024.03.004)

## Topics

Hepatocellular carcinoma · intra-tumor heterogeneity · inter-tumor heterogeneity · Patient-derived organoid · Organoid biobank · pharmacogenomic profiling · drug sensitivity screening · Precision medicine · lenvatinib resistance · c-Jun · JNK signaling · Wnt/β-catenin signaling pathway · multi-gene expression signatures · patient stratification · genomic landscape · transcriptomic characteristics · Hepatocellular carcinoma · Combination therapy · veratramine · PKUF-01 · Drug synergy · Predictive biomarker · drug response prediction · histopathology recapitulation · Patient-derived organoid · biomarker panels · tumor heterogeneity landscape · clinically relevant drugs · In vivo models · c-Jun inhibitor

## Cite this ranking

```
Pepkio Research Index (PRI). Topics and Trends in Most Cited Hepatocellular Carcinoma Treatment and Prognosis Papers, Class of 2026. https://pri.pepkio.com/top-papers/hepatocellular-carcinoma-treatment-and-prognosis/2026. Accessed 2026-07-14.

Zheng Su, Tinsley Li, Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis. bioRxiv 2026.07.04.736459; doi: https://doi.org/10.64898/2026.07.04.736459
```